What Is the Risk of Permanent Sexual Dysfunction from Antidepressants?
Males taking antidepressants were at 100 times the risk of erectile dysfunction compared with the healthy population and more than three times the risk even after controlling for other variables.
Placebo Effect—Not Antidepressants—Responsible for Depression Improvement
In adolescent depression treatment, those who received a placebo but thought they received Prozac improved more than those who received the drug and knew it.
After the Black-Box: Majority of Children Starting SSRIs Still Receiving Too High of Dose
In 2004, the FDA added a black-box warning to SSRI antidepressants on the increased risk of suicide among children taking these drugs. A new study suggests that this warning has increased the proportion of children who begin an antidepressant on a low dose, but the majority are still receiving higher than recommended doses.
Antidepressant Use More Than Doubles Risk of Suicide Attempts
Throughout the past two decades, studies have warned of increased suicide rates in those taking antidepressants, especially in children and adolescents. Researchers also documented...
Lexapro for Children: Drug With No Meaningful Benefit and Increased Suicidality Gets FDA Approval
Response and remission rates were the same in the drug versus placebo groups, and Lexapro increased suicidality sixfold.
How to Distinguish Antidepressant Withdrawal from Relapse
Mark Horowitz and David Taylor provide advice on how to tell the difference between antidepressant withdrawal and depression relapse.
Understanding the Neurobiology of Post-SSRI Sexual Dysfunction
Post-SSRI sexual dysfunction (PSSD) may be a common adverse effect of antidepressants. Researchers are now attempting to understand the neurobiology behind it.
Antidepressants Increase Risk of Death, Study Finds
Antidepressants are commonly considered safe and effective treatments. However, research has questioned their efficacy, and now, their safety.
Giovanni Fava – A Different Psychiatry is Possible
In this podcast, we hear from the renowned clinician and researcher Dr. Giovanni Fava about his latest book entitled “Discontinuing Antidepressant Medications”.
Long Term Antidepressant Use Associated With Increased Morbidity and Mortality
A study finds that commonly prescribed antidepressants are associated with the development of diabetes, hypertension, and other diseases.
Antidepressant Withdrawal Linked to Suicide Attempt in Case Study
Researchers suggest that antidepressant withdrawal can be a possible precipitant of suicide.
Antidepressant Withdrawal Misdiagnosed as Functional Disorder
Adverse physiological symptoms of antidepressant withdrawal are regularly mistaken to be other problems to the detriment of the patient.
Did Psychiatry Ever Endorse the Chemical Imbalance Theory of Depression?
With the chemical imbalance theory falling out of fashion, researchers examine the claim that psychiatry never truly endorsed it.
Largest Meta-Analysis of Antidepressants Finds Doubled Risk of Suicide in Youth
The largest-ever meta-analysis of antidepressant trials appeared yesterday in the British Medical Journal. Researchers from the Cochrane Collaboration reviewed 70 trials (involving 18,526 subjects), to find that - counter to the initially-reported findings - antidepressants doubled the risk of suicide and aggression in subjects under 18. This risk had been misrepresented in the original study reports, the authors say, and suggest that the risks to adults may be similarly under-reported.
Listening to the Patient Voice: The Antidepressant Withdrawal Experience
Patient advocates join with researchers and service users to present first-hand experiences of antidepressant withdrawal.
How Do Antidepressants Really ‘Work’?
A recent review, published in Neuroscience & Biobehavioral Reviews, challenges the dominant assumptions about the neurochemical and therapeutic effects of Selective Serotonin Reuptake Inhibitors...
Antidepressant Trials “Hijacked for Marketing Purposes,” Researchers Say
About half of the large antidepressant trials are biased enough to be considered “seeding trials,” according to the researchers.
SSRI Use During Pregnancy Alters the Child’s Brain Development
Reduced brain volumes due to SSRI exposure in pregnancy was not explained by maternal depression alone.
Use of Antidepressants Linked to Diabetes
Selective serotonin reuptake inhibitors (such as Prozac and Zoloft) are the most commonly prescribed medication for depression. SSRIs have long been associated with an...
Antidepressant Use Leads to Worse Long Term Outcomes, Study Finds
Results from a 30-year prospective study demonstrated worse outcomes for people who took antidepressants, even after controlling for gender, education level, marriage, baseline severity, other affective disorders, suicidality, and family history of depression.
Further Results Confirm Antidepressants Increase Risk of Violent Crime By 26%
Taking an SSRI antidepressant was associated with a 26% increased risk of violent crime conviction.
Interview: Researcher Runs Trial on Antidepressant Withdrawal
Tony Kendrick, a professor of Primary Care at the University of Southampton, has found through his research and practice that too many people are being prescribed antidepressants long-term without the information and support necessary to get off of them.
Antidepressants Not Clinically Useful for Back Pain
While professional guidelines recommend antidepressants for back pain, researchers point out the lack of evidence for their usefulness.
NICE Guideline Update Acknowledges Severe Antidepressant Withdrawal
A new update to the NICE guideline for depression suggests providers discuss long-term, severe antidepressant withdrawal symptoms.
Researchers: It’s Time to Stop Recommending Antidepressants for Depression
Researchers review a new synthesis of the existing evidence and conclude that the harms of antidepressants outweigh any benefits.