Antidepressants

Researchers found that rats born to mothers given the antidepressant Prozac during pregnancy or breastfeeding exhibited varied behavioral and developmental effects, with implications for the understanding of antidepressant impacts during human pregnancies.

Mark Horowitz and David Taylor provide advice on how to tell the difference between antidepressant withdrawal and depression relapse.

Post-SSRI sexual dysfunction (PSSD) may be a common adverse effect of antidepressants. Researchers are now attempting to understand the neurobiology behind it.

Researchers find that SSRIs increase suicide attempts up to age 24, and have no preventative effect at any age, even for those at high risk of suicide.

A new study conducted by Jeffrey Vittengl at Truman University has found that taking antidepressant medications resulted in more severe depression symptoms after nine years.

A new study finds that newborn babies experience antidepressant withdrawal after birth if their mothers take SSRIs when pregnant.

For the past 15 years, the VA's suicide prevention efforts have focused on getting veterans screened and treated for psychiatric disorders, with antidepressants a first-line therapy. This effort has caused veteran suicide rates to steadily rise.

An analysis of FDA adverse event reports related to esketamine shows the potential for negative effects such as suicidal and self-injurious ideation.

A new study published in Frontiers in Psychiatry concludes that “antidepressants are largely ineffective and potentially harmful.”

Had I known what I know now, I never would have taken any of these drugs, and I absolutely would not have taken a role in which my outreach efforts to get veterans into mental health treatment might place thousands of lives at risk.

A new review, published in BMJ Evidence-Based Medicine, concludes that antidepressants should not be used as the risks outweigh evidence for benefits.

A study finds that commonly prescribed antidepressants are associated with the development of diabetes, hypertension, and other diseases.

The initial study, which has been used to promote antidepressants, employed outcome switching to hide poor results.

In a real-world setting, less than a quarter of patients diagnosed with depression improved with medication, hospitalization, and therapy.

Selective publication bias in top psychiatry journals was not explained by the quality of the studies, but by financial ties to pharma.

Researchers, Jon Jureidini, Jay Amsterdam and Leemon McHenry, have taken a closer look at the data from a randomized control trial of citalopram (Celexa) that was ghostwritten and then used by the manufacturers to support claims of the drug’s efficacy and safety in the treatment of child and adolescent depression. To get the background on this story, we connected with Dr. Leemon McHenry, an investigator in this study and a lecturer in philosophy at California State University, Northridge.

Author William Styron is often remembered for speaking about depression as an illness. But a review of his life reveals that psychiatric drugs may have triggered and even worsened his depressive episodes.

Researchers interviewed people who were given medical advice to discontinue antidepressants.

A new update to the NICE guideline for depression suggests providers discuss long-term, severe antidepressant withdrawal symptoms.

Antidepressants are commonly considered safe and effective treatments. However, research has questioned their efficacy, and now, their safety.

Researchers suggest that antidepressant withdrawal can be a possible precipitant of suicide.

Results from a 30-year prospective study demonstrated worse outcomes for people who took antidepressants, even after controlling for gender, education level, marriage, baseline severity, other affective disorders, suicidality, and family history of depression.

Babies born to mothers taking antidepressants during pregnancy were more than six times as likely to have neonatal withdrawal syndrome—including breathing problems, irritability/agitation, tremors, feeding problems, and seizures—than those born to mothers taking other types of drugs.

Study reveals most patients are dissatisfied with prescribers' support when discontinuing antidepressants.

Survey examines adverse personal and interpersonal effects of antidepressants and the impact of polypharmacy