Therapy Beats Drugs for Depression for Long-Term Outcomes

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Combining drugs and therapy also did not lead to better depression outcomes than therapy alone.

Antidepressants Still Linked to Increased Suicide Risk

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Bias and financial conflicts in antidepressant trials “contribute to systematic underestimation of risk in the published literature.”

Antidepressant Exposure In Utero May Negatively Impact Motor Skills in 2-Year-Old Children

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A new study in Frontiers of Pharmacology finds that antidepressant use during pregnancy is linked to reduced motor skills in children at 2 years...

Antidepressant Use Tightly Correlates with Increased Suicide Rates

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While the study can’t confirm causality, it does contradict the notion that antidepressants reduce suicide at the population level.

Allen Frances Takes on the Over-Prescription of Antidepressants

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The prominent psychiatrist explores why antidepressants remain highly overprescribed and offers solutions to the problem.
Illustration of a shape of a baby crawling made out of various types of pills, on a black background

Health Risks to Babies When Antidepressants Used During Pregnancy

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Babies born to mothers taking antidepressants during pregnancy were more than six times as likely to have neonatal withdrawal syndrome—including breathing problems, irritability/agitation, tremors, feeding problems, and seizures—than those born to mothers taking other types of drugs.

Researchers Document Protracted Withdrawal from Antidepressants

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Protracted Withdrawal Syndrome characterized by long-term adverse experiences after coming off of antidepressants.

Newborn Babies Go Through Antidepressant Withdrawal

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A new study finds that newborn babies experience antidepressant withdrawal after birth if their mothers take SSRIs when pregnant.

Fear and Belief in “Chemical Imbalance” Prevent People from Coming Off Antidepressants

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Researchers interviewed people who were given medical advice to discontinue antidepressants.

New Data Reveal the Full Extent of STAR*D Failure

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The initial study, which has been used to promote antidepressants, employed outcome switching to hide poor results.

Less Than a Quarter of Those with Depression Respond to Treatment in Real Life

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In a real-world setting, less than a quarter of patients diagnosed with depression improved with medication, hospitalization, and therapy.

SSRIs in Pregnancy Linked to Early Depression in Children

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A new study finds that prenatal exposure to antidepressant drugs, known as selective serotonin reuptake inhibitors or SSRIs, is associated with higher rates of...
Battle of the brains and war of wit concept as two opposing open human brain symbols fighting as a debate or dispute metaphor and an icon for creative competition in a 3D illustration style.

Pharma CEO, Others Attempt Contradictory Critiques of Serotonin-Debunking Study

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Moncrieff et al. respond to the contradictory and, in some cases, false concerns raised by these critics of their serotonin review.

No Matter Which Measure You Use, Antidepressants Aren’t That Effective

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Researchers compared the efficacy of antidepressants using different rating scales and found them to be no different—just slightly better than placebo, and not meeting the criteria for clinical significance.

Antidepressant Use in Pregnancy Harms Child Development, Untreated Maternal Depression Shows Benefit

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In this new study, exposure to maternal anxiety in utero also harmed child development.
Pile of pills in blister packs background

Psychiatric Journals’ Pro-Pharma Publication Bias Hides Suicide Risk of Antidepressants

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Selective publication bias in top psychiatry journals was not explained by the quality of the studies, but by financial ties to pharma.

The Effects of Antidepressant Exposure Across Generations: An Interview with Dr. Vance Trudeau

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Dr. Vance Trudeau discusses his study's finding that antidepressants may have far-reaching, adverse effects that last up to three generations.

Antidepressants Linked to Heart Arrhythmias

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Researchers from the Mass General and Brigham & Women's Hospitals and the Mt. Sinai School of Medicine find, using data from electronic health records...

Withdrawal from Antidepressants

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A review of the scientific literature related to withdrawal from antidepressants: mechanism of action; long-term effects of exposure to antidepressants; discontinuation syndromes; relapse upon discontinuation; tapering protocols.

Antidepressant Effects Thwarted by Stressful Environments

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A new study, about to be published in the journal Brain, Behavior, and Immunity, investigates the role a stressful environment plays in antidepressant effectiveness....

Antidepressant Misinformation Promoted on Popular Websites

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A new study indicates that popular online resources do not accurately present the scientific evidence on the risks and benefits of antidepressants.

The Whistleblower and Penn: A Final Accounting of Study 352

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After 18 years, the full story of the scientific corruption in a study of paroxetine for bipolar disorder, and the psychiatrist who blew the whistle.

Rigorous Study Finds Antidepressants Worsen Long-Term Outcomes

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A new study conducted by Jeffrey Vittengl at Truman University has found that taking antidepressant medications resulted in more severe depression symptoms after nine years.

Gradual Tapering Recommended for Antidepressant Discontinuation

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A new literature review reinforces the need to “down-titrate” or taper antidepressants, especially drugs like Celexa and Paxil.

Researchers: Antidepressant Withdrawal, Not “Discontinuation Syndrome”

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Researchers suggest that the pharmaceutical industry had a vested interest in using the term “discontinuation” in order to hide the severity of physical dependence and withdrawal reactions many people experience from antidepressants.