Antidepressants

Bias and financial conflicts in antidepressant trials “contribute to systematic underestimation of risk in the published literature.”

Tony Kendrick, a professor of Primary Care at the University of Southampton, has found through his research and practice that too many people are being prescribed antidepressants long-term without the information and support necessary to get off of them.

Researchers, Jon Jureidini, Jay Amsterdam and Leemon McHenry, have taken a closer look at the data from a randomized control trial of citalopram (Celexa) that was ghostwritten and then used by the manufacturers to support claims of the drug’s efficacy and safety in the treatment of child and adolescent depression. To get the background on this story, we connected with Dr. Leemon McHenry, an investigator in this study and a lecturer in philosophy at California State University, Northridge.

After 18 years, the full story of the scientific corruption in a study of paroxetine for bipolar disorder, and the psychiatrist who blew the whistle.

Survey examines adverse personal and interpersonal effects of antidepressants and the impact of polypharmacy

For those with severe depression, inpatient CBT was effective but the adding antidepressants did not improve treatment outcomes.

Researchers interviewed people who were given medical advice to discontinue antidepressants.

A new study indicates that popular online resources do not accurately present the scientific evidence on the risks and benefits of antidepressants.

Researchers review a new synthesis of the existing evidence and conclude that the harms of antidepressants outweigh any benefits.

Selective serotonin reuptake inhibitors (such as Prozac and Zoloft) are the most commonly prescribed medication for depression. SSRIs have long been associated with an...

With the chemical imbalance theory falling out of fashion, researchers examine the claim that psychiatry never truly endorsed it.

Moncrieff et al. respond to the contradictory and, in some cases, false concerns raised by these critics of their serotonin review.

The August issue of Psychotherapy and Psychosomatics published a review conducted by André F. Carvalho and colleagues regarding the literature around the long-term use...

Antidepressants are commonly considered safe and effective treatments. However, research has questioned their efficacy, and now, their safety.

According to patient reports, SSRI antidepressants most frequently lead to the subjective experience of emotional blunting.

A group of researchers in Denmark examines what existing animal studies can tell us about the sexual side-effects of SSRI antidepressants.

New guidance for primary care doctors in the UK on antidepressant discontinuation acknowledges severe and long-lasting withdrawal symptoms.

Dr. Vance Trudeau discusses his study's finding that antidepressants may have far-reaching, adverse effects that last up to three generations.

A review of the scientific literature related to withdrawal from antidepressants: mechanism of action; long-term effects of exposure to antidepressants; discontinuation syndromes; relapse upon discontinuation; tapering protocols.

The largest-ever meta-analysis of antidepressant trials appeared yesterday in the British Medical Journal. Researchers from the Cochrane Collaboration reviewed 70 trials (involving 18,526 subjects), to find that - counter to the initially-reported findings - antidepressants doubled the risk of suicide and aggression in subjects under 18. This risk had been misrepresented in the original study reports, the authors say, and suggest that the risks to adults may be similarly under-reported.

Researchers report the cumulative effects of major biases on the apparent efficacy of antidepressant and psychotherapy treatments.

A review of research on antidepressant efficacy finds that an unfavorable risk-to-benefit ratio.

Study reveals most patients are dissatisfied with prescribers' support when discontinuing antidepressants.

Royal College of Psychiatrists’ former president demands support for patients coming off antidepressants.

A Molecular Psychiatry study found that people who had recurrent depression developed smaller hippocampi and antidepressants protected against that effect -- except insofar as the study evidence seemed to show the opposite of what the media reported on it.