Monday, February 6, 2023

Tag: antidepressant discontinuation

Researchers Identify Factors to Predict Risk of Antidepressant Withdrawal

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Paroxetine, SNRIs, and MAOIs were associated with the highest risk of withdrawal, as was long duration of use and whether the person experienced withdrawal in the past.

A Different Psychiatry Is Needed for Discontinuing Antidepressants

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The problems related to the use of antidepressants cannot be solved by an oversimplified psychiatry brainwashed by the pharmaceutical industry.

Psychology: Flawed as a Science and as Evidence-Based Medicine

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Peter Simons covers a paper arguing that “psychology is fundamentally incompatible with hypothesis-driven theoretical science,” another paper finding that evidence-based medicine is more corporate gimmick than reliable science, a study that found psychiatrists deliver the worst-quality healthcare of any medical specialty, and more!

How to Distinguish Antidepressant Withdrawal from Relapse

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Mark Horowitz and David Taylor provide advice on how to tell the difference between antidepressant withdrawal and depression relapse.

Withdrawal Symptoms Cloud Findings of Antidepressant “Relapse” Trial

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Leading researchers point out that a new antidepressant study in NEJM failed to account for withdrawal symptoms, casting doubt on the results.

“Relapse” in Antidepressant Trials Likely Caused by Sudden Withdrawal

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A new study investigates how antidepressant withdrawal effects often get confounded with depression relapse in clinical trials.

Cochrane Review Calls for More Research on Antidepressant Withdrawal

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Researchers find a lack of current literature on safe, effective ways to manage antidepressant withdrawal and make suggestions for future research.

Researchers Document Protracted Withdrawal from Antidepressants

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Protracted Withdrawal Syndrome characterized by long-term adverse experiences after coming off of antidepressants.

Surviving Antidepressants: An Interview with Adele Framer

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That is the truth about withdrawal syndrome: It’s like a 50-50 chance that you’re going to have a problem. If you’re in the unlucky half, you’re gonna be really unlucky.

The Reckoning in Psychiatry Over Protracted Antidepressant Withdrawal

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Medically-induced harm—affecting tens of millions of people worldwide—has taken the field decades to take seriously.

How Academic Psychiatry Minimized SSRI Withdrawal

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If academic psychiatry is evidence-based, why did it take two decades to recognize SSRI withdrawal as widespread and chronic among patients?

Tapering Strips Help People Stop Using Antidepressants, Study Finds

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A new study by Peter Groot and Jim van Os investigated whether tapering strips can help people stop using antidepressants.

SSRI Withdrawal’s Elephant in the Room: Tardive Akathisia

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Slower tapering of antidepressant dose is generally more comfortable. However, success or failure after stopping completely mostly relates to whether tardive akathisia occurs.

Gabapentin Horror

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After suffering PTSD in the late 1980s, I reluctantly accepted antidepressants. In time, I had resolved the trauma, but when I tried to stop the antidepressants (Prozac, and later Zoloft), I assumed my desperate feelings and “return” of depression were an indication I had an imbalance and needed those drugs. I didn’t understand I was experiencing withdrawal. (I was never told that for most people, psychiatric medications need to be tapered.)

Missing a Pivotal Outcome in a Large Cold Turkey Trial of...

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In June 2014, Arif Khan et al. published a trial of 361 patients randomised to three groups: abrupt versus 1-week taper versus no discontinuation of desvenlafaxine. Curiously, although all patients had depression, the readers were told that data on depressive symptoms “are reported elsewhere.”

The Review on Antidepressant Withdrawal That Cochrane Won’t Publish

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Peter Gøtzsche and Anders Sørensen on trying to get a review of methods for safe antidepressant withdrawal published in Cochrane: "They sent us on a mission that was impossible to accomplish" to "protect the psychiatric guild."

Researchers: Antidepressant Withdrawal, Not “Discontinuation Syndrome”

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Researchers suggest that the pharmaceutical industry had a vested interest in using the term “discontinuation” in order to hide the severity of physical dependence and withdrawal reactions many people experience from antidepressants.

Fear and Belief in “Chemical Imbalance” Prevent People from Coming Off...

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Researchers interviewed people who were given medical advice to discontinue antidepressants.

Why Don’t Prescribers Discuss Antidepressant Discontinuation?

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In a new study, prescribers identify barriers to discussing antidepressant discontinuation with patients.

Psychological Interventions Can Help When Tapering Off Antidepressants

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Meta-analysis of antidepressant tapering finds CBT and MBCT can aid in tapering, but limited studies met inclusion criteria.

My Fight Against Antidepressants, Part III: Breaking Free

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I had managed to get off the drugs again, this time with practically no withdrawal reactions other than some disturbances to my sleep which eventually settled down. I truly feel that I have been given a second chance because I am aware of how many people struggle terribly with these drugs just as I did.

New Study Explores Approaches to Discontinuing Antidepressants

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Psychiatrist and psychologist outline pharmacological and psychotherapeutic strategies for discontinuing antidepressants.

How Antidepressant Withdrawal ‘Can Trap People’

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Psychiatrist Dr Allen Frances argues when people face "mild, transient depression," antidepressants shouldn't become "a way of treating the aches and pains of everyday life."

Antidepressant Withdrawal, Online Data, and a Bottom Line

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In this piece for Psychiatric Times, James Phelps MD writes about the lack of official data on the number of people trying to come off antidepressants and mentions the work of the peer support organisation Surviving Antidepressants.

Letter to The New York Times: Many People Taking Antidepressants Discover...

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Ten years ago, the recent New York Times article entitled “Many People Taking Antidepressants Discover They Can’t Quit” would have shocked me. I would have dismissed serious medication withdrawal as rare. But I tell my patients something different today.