Neuroleptic Malignant Syndrome

Patients who recover from a single episode of psychosis are often prescribed antipsychotics long-term, despite a lack of evidence for this practice

Despite the fact that clinical practice guidelines specifically recommend against the use of more than one antipsychotic at once, new research reveals that as...

Increased Parkinson's risk could be related to lithium, antipsychotic, and antiepileptic drug use.

Researchers reveal the limitations and misleading interpretations of two recent studies that claim to demonstrate that long-term antipsychotic use leads to better outcomes.

The US Food and Drug Administration has announced that there will soon be a public meeting to explore providing drug companies with greater flexibility in promoting off-label indications to doctors. When it comes to prescribing medications to children, and particularly psychiatric medications, this is a bad idea. I write both as a former consultant to the pharmaceutical industry, and as a father who lost a son to the toxic effects of antipsychotics prescribed off-label.

Following a lawsuit brought by Andrew Thibault of Parents Against Pharmaceutical Abuse (PAPA), the FDA has produced adverse event and severe adverse event reports...

Sir Robin Murray, a professor at the Institute of Psychiatry, Psychology, and Neuroscience in London, states that he ignored social factors that contribute to ‘schizophrenia’ for too long. He also reports that he neglected the negative effects antipsychotic medication has on the brain.

A new study has found that children and adolescents taking a high dose of antipsychotics are almost twice as likely to die of any cause than children on other types of medications.

On his website, Dr. Nardo details the hidden risks and bad science behind the growing practice of using atypical antipsychotics to augment antidepressant treatment for severe depression. The story of Atypical Antipsychotic Augmentation of Treatment Resistant Depression is a “prime example” “to illustrate how commercial interests have invaded medical practice.” “Besides the obvious dangers of the Metabolic Syndrome and Tardive Dyskinesia, these drugs don’t really do what they’re advertised to do – make the antidepressants work a lot better.”

How does physical activity affect people diagnosed with bipolar, schizophrenia and major depressive disorders?

The Santa Cruz Sentinel reports on legislation being passed in California to go after physicians who overprescribe psychiatric drugs to foster youth. The proposed legislation also targets government agencies that fail to offer nondrug alternative therapies to help foster youth recover from traumatic childhoods.

From National Post: Many physicians are prescribing a low dose of Seroquel, an atypical antipsychotic, to patients with insomnia. Experts warn that even a low...

On November 12th, 2015, the third anniversary of the day that I abruptly stopped taking benzodiazepines, my dear friend, J. Doe, published a two-part article here on Mad in America examining the language that is commonly used to describe benzodiazepine (benzo) iatrogenesis. I wanted a summary of these articles captured in a Youtube video so that those in the thick of benzo neurotoxicity could tune into these ideas in a way that might be more easily digestible. I hoped more benzo sufferers would begin to question how they describe (and allow others to describe) an illness that remains decades behind in understanding and recognition. I also wanted to draw attention to the content again in hopes that more medical professionals would read and understand the crucial distinctions in language surrounding this problem.

In a study published yesterday, researchers from the Nippon Medical School in Tokyo bring attention to a condition known as neuroleptic-induced deficit syndrome (NIDS)...

Neuroleptic Drugs and Violence by Catherine Clarke SRN, SCM, MSSCH, MBChA. and Jan Evans MCSP. Grad Dip Phys.

A new study published this month in the journal Neuron identifies the mechanism by which antipsychotic drugs can induce parkinsonism, a condition involving movement...

When I was born, everyone was expecting me to have arms. The doctor's mind raced; how am I going to tell this mother and the father that their son has hands but not arms? If he's missing so much in his extremities, mustn’t he also be missing a mind? My mom looked into my eyes and knew - in a way that only mothers know - that I had a mind, and spirit.

Research from London and Taipei finds that neuroleptic malignant syndrome (NMS) is associated with the number of different antipsychotics used (polypharmacy), rather than the overall...

Drug makers have faced large fines for unethical and harmful practices but have simply treated these as a cost of doing business. Ed Silverman reports...

People who reduced antipsychotic use by tapering were doing just as well after five years as those who continued using the drugs.

A new special issue brings together articles exploring the harmful effects of simultaneous multiple medication use.

Researchers from the City College of New York and Columbia University published a study this month testing the hypothesis that people diagnosed with schizophrenia treated long-term with antipsychotic drugs have worse outcomes than patients with no exposure to these drugs. They concluded that there is not a sufficient evidence base for the standard practice of long-term use of antipsychotic medications.

More than ten-percent of adults in the United States are currently prescribed at least one psychiatric medication but there is currently a lack of research on the prevalence of adverse drug events (ADEs) associated with these prescriptions outside of clinical trials.

A large review and meta-analysis of 167 studies across 60 years dissects placebo-controlled randomized controlled trials of antipsychotic drugs.

A recent RCT showed that vitamin B6 is as effective as propranolol for the treatment of akathisia.