Neuroleptic Malignant Syndrome

Review study compares outcomes of gradual vs. immediate antipsychotic discontinuation when switching from one drug to another.

Analysis of longitudinal data from 2000-2014 demonstrate mortality gap is widening between persons with a diagnosis of bipolar or schizophrenia compared to the general population

In a study published yesterday, researchers from the Nippon Medical School in Tokyo bring attention to a condition known as neuroleptic-induced deficit syndrome (NIDS)...

People who reduced antipsychotic use by tapering were doing just as well after five years as those who continued using the drugs.

Drug makers have faced large fines for unethical and harmful practices but have simply treated these as a cost of doing business. Ed Silverman reports...

Following a lawsuit brought by Andrew Thibault of Parents Against Pharmaceutical Abuse (PAPA), the FDA has produced adverse event and severe adverse event reports...

Patients who recover from a single episode of psychosis are often prescribed antipsychotics long-term, despite a lack of evidence for this practice

Antipsychotics present a known risk for major side effects. A new study suggests that certain antipsychotics may present a greater risk for cardiovascular disease than others.

A recent RCT showed that vitamin B6 is as effective as propranolol for the treatment of akathisia.

Researchers believe that side-effect monitoring is critical because of the increase in the use of antipsychotics

When I was born, everyone was expecting me to have arms. The doctor's mind raced; how am I going to tell this mother and the father that their son has hands but not arms? If he's missing so much in his extremities, mustn’t he also be missing a mind? My mom looked into my eyes and knew - in a way that only mothers know - that I had a mind, and spirit.

Neuroleptic Drugs and Violence by Catherine Clarke SRN, SCM, MSSCH, MBChA. and Jan Evans MCSP. Grad Dip Phys.

More than ten-percent of adults in the United States are currently prescribed at least one psychiatric medication but there is currently a lack of research on the prevalence of adverse drug events (ADEs) associated with these prescriptions outside of clinical trials.

From National Post: Many physicians are prescribing a low dose of Seroquel, an atypical antipsychotic, to patients with insomnia. Experts warn that even a low...

How does physical activity affect people diagnosed with bipolar, schizophrenia and major depressive disorders?

Researchers from the City College of New York and Columbia University published a study this month testing the hypothesis that people diagnosed with schizophrenia treated long-term with antipsychotic drugs have worse outcomes than patients with no exposure to these drugs. They concluded that there is not a sufficient evidence base for the standard practice of long-term use of antipsychotic medications.

A new special issue brings together articles exploring the harmful effects of simultaneous multiple medication use.

A new study has found that children and adolescents taking a high dose of antipsychotics are almost twice as likely to die of any cause than children on other types of medications.

“Do they make people less aggressive? Yes, sometimes they do. Will they sedate people? Absolutely. Will they make kids easier to manage? They will,” Robert Whitaker tells Liz Spikol for Philadelphia Magazine. “But I know of no study that shows that medicating these kids long-term will help them grow up and thrive. The developing brain is a very delicate thing. The narrative is that these side effects are mild, and that’s just not true, and that the benefits are well-established, and so often they’re not.”

A new study published this month in the journal Neuron identifies the mechanism by which antipsychotic drugs can induce parkinsonism, a condition involving movement...

Despite the fact that clinical practice guidelines specifically recommend against the use of more than one antipsychotic at once, new research reveals that as...

The Cochrane Library reports that "many older people with Alzheimer's dementia and NPS (neuropsychiatric symptoms) can be withdrawn from chronic antipsychotic medication without detrimental effects...

Researchers point to the risks of using antipsychotics with youth and caution against the practice.

On his website, Dr. Nardo details the hidden risks and bad science behind the growing practice of using atypical antipsychotics to augment antidepressant treatment for severe depression. The story of Atypical Antipsychotic Augmentation of Treatment Resistant Depression is a “prime example” “to illustrate how commercial interests have invaded medical practice.” “Besides the obvious dangers of the Metabolic Syndrome and Tardive Dyskinesia, these drugs don’t really do what they’re advertised to do – make the antidepressants work a lot better.”

Martha Rosenberg highlights how the popular antipsychotic Seroquel is a perfect example of how direct-to-consumer advertising made billion dollar blockbuster drugs possible before side-effects...