Off-label

From Next Avenue: The drug Nuedexta has only been approved for patients with multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). However, the maker of...

Differences in patient-centric versus service-centric measures make quantifying low-value care difficult.

The paradox of relieving chronic pain with an antidepressant (and a new set of symptoms).

Majority of top-selling and most promoted drugs in Canada are rated as having very limited safety and efficacy.

One-third of adults with an intellectual or developmental disability are dispensed antipsychotics, despite having no existing psychiatric diagnosis.

Leading human subjects ethics researcher questions exploitation of uninsured minorities in experimental drug trials.

Large cohort study demonstrates that those with an intellectual disability are at an increased risk for movement disorder side effects of antipsychotics.

From Kirkus Reviews: In his new book Mental Health, Inc., Art Levine reports on the dire state of the U.S. mental health system. "The author delivers the...

The researchers found that, of those who were initially prescribed both antidepressants and benzodiazepines, approximately 12% went on to engage in long-term benzodiazepine use.

Surveyed doctors overestimate pharmacological effects of antidepressants and underestimate placebo effects.

A new paper published in Bioethics assesses proposals to “enhance morality” through neuropharmacological and neurotechnological interventions.

Implementing policies that regulate pharmaceutical sales representatives’ interaction with physicians may reduce prescription of promoted drugs.

In this piece for The Cut, Dyan Neary details the story of Frankie Perry, a man whose life was forever altered by being prescribed an...

Researchers found that veterans with both conditions had higher odds of being prescribed second-generation antipsychotics than those presenting with just PTSD.

Researchers provide an action-planning framework to engage providers in the reduction of low-value healthcare.

A new study links direct-to-consumer (DTC) advertising to increased testosterone treatment, even when patients do not have a diagnosable condition.

Study finds more patients are visiting physicians who have ties to industry than previously thought.

Organizations, advocates, scholars, and practitioners had a chance to give feedback regarding FDA processes.

False beliefs about biological differences between races are associated with a failure to provide recommended pain treatments to Black people.

A new study, published in the British Medical Journal, investigates the prevalence of off-label prescribing for antidepressant medication in primary care settings.

Behind the U.S. task force recommendation to screen all children and adults for depression.

An article published this month in the journal BMC Psychiatry suggests that there is a lack of efficacy for SSRIs and that they significantly increase the risk of serious side effects.

From the Center for Health Journalism: President Trump's plans to speed up the process of FDA drug approvals, in combination with the increase of off-label...

The researchers suggest that developmental immaturity is mislabelled as a mental disorder and unnecessarily treated with stimulant medication

Despite little evidence for benefit, and substantial risk of harm, antipsychotics are commonly prescribed to children diagnosed with ADHD