Increased Suicidality in Cymbalta Trial for Fibromyalgia in Teens

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A new as-yet-unpublished trial of duloxetine (Cymbalta) for fibromyalgia has presented more evidence of suicidal events in teens.

Pooling Data May Hide Negative Outcomes for Antidepressants

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A new study, published in Psychological Medicine, found evidence for a specific type of publication bias distorting the evidence about antidepressant efficacy.

Reanalysis of STAR*D Study Suggests Overestimation of Antidepressant Efficacy

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Reanalysis of the original primary outcome measure in the STAR*D study suggests STAR*D findings inflate improvement on antidepressant medication and exclusion criteria in conventional clinical trials results in overestimation of antidepressant efficacy.

Researcher Challenges Clinical Effectiveness of Antidepressants

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A new article in BMJ Evidence-Based Medicine addresses common misinterpretations of the efficacy research on antidepressants.

Adolescent Suicide and The Black Box Warning: STAT Gets It All Wrong

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STAT recently published an opinion piece arguing that the black box warning on antidepressants has led to an increase in adolescent suicide. It is easily debunked, and reveals once again how our society is regularly misled about research findings related to psychiatric drugs. STAT has lent its good name to a false story that, unfortunately, will resonate loudly with the public.

SSRI Exposure in Pregnancy Alters Fetal Neurodevelopment

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Alterations in gray matter and white matter development found in infants of mothers taking SSRI antidepressants during pregnancy.

Publication Bias Inflates Perceived Efficacy of Depression Treatments, Study Finds

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Researchers report the cumulative effects of major biases on the apparent efficacy of antidepressant and psychotherapy treatments.

Study Shows Poor Outcomes for the Treatment for Childhood Anxiety

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New research identifies poor long-term outcomes for both CBT and medications for treating anxiety disorders in childhood.

Citizens Petition Calls for Sexual Side Effect Warnings

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Researchers take action after study exposes enduring sexual dysfunction as a potential side effect of serotonin reuptake inhibiting antidepressants, 5α-reductase inhibitors, and isotretinoin.

Researcher Critiques Misleading Media Coverage of Lancet Antidepressant Meta-Analysis

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The BMJ’s clinical editor takes issue with uncritical media coverage of antidepressant network meta-analysis, outlining reporting missteps.

Antidepressants Are Not More Effective for Severe Depression, Study Finds

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A new study, published in Acta Psychiatrica Scandinavica, found that antidepressant efficacy was not dependent on severity.

Review of Pediatric Antidepressant Studies Finds Evidence of Benefit Lacking

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Review of pediatric antidepressant studies finds the vast majority are negative on primary outcomes and an increased risk for suicidality.

Review Finds Lack of Evidence for Antidepressants in Treatment of Insomnia

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Results from a Cochrane meta-analysis find that the common practice of prescribing antidepressants to treat insomnia is not supported by current evidence.

Increasing Antidepressant Dose Does Not Improve Outcomes

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A systematic review of literature and meta-analysis indicates that there is no clinically or statistically significant effect of antidepressant dose increase after nonresponse to initial treatment.

Antidepressant Use Leads to Worse Long Term Outcomes, Study Finds

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Results from a 30-year prospective study demonstrated worse outcomes for people who took antidepressants, even after controlling for gender, education level, marriage, baseline severity, other affective disorders, suicidality, and family history of depression.

New Study Concludes that Antidepressants are “Largely Ineffective and Potentially Harmful”

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A new study published in Frontiers in Psychiatry concludes that “antidepressants are largely ineffective and potentially harmful.”

Anticholinergic Medications Linked to Dementia Similar to Early Alzheimer’s

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A new study, published in the Journal of Clinical Psychiatry, investigates the effects of anticholinergic medications, such as antidepressants and antipsychotics, on cognition in older adults diagnosed with schizophrenia.

Antidepressants During Pregnancy Increase Risk of Psychiatric Diagnosis in Children

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New research, based on data from almost a million children in Denmark, suggests that children of mothers who use antidepressants during pregnancy are more likely to be diagnosed with autism and psychiatric disorders.

New Research on Prenatal SSRI Exposure and Autism

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Does maternal SSRI exposure increase the chances that a child will develop characteristics associated with Autism Spectrum Disorder (ASD)?

SSRI Ineffective at Treating Depression in Individuals with Chronic Kidney Disease

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Dr. Madhukar Trivedi and colleagues find that the SSRI sertraline does not reduce depressive symptoms any more than placebo in people with Chronic Kidney Disease.

Rigorous Study Finds Antidepressants Worsen Long-Term Outcomes

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A new study conducted by Jeffrey Vittengl at Truman University has found that taking antidepressant medications resulted in more severe depression symptoms after nine years.

Antidepressant Use May Increase Risk of Diabetes

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New study confirms previous evidence that antidepressant use is linked to developing type 2 diabetes.

Antidepressants Increase Risk of Death, Study Finds

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Antidepressants are commonly considered safe and effective treatments. However, research has questioned their efficacy, and now, their safety.

Replacing Pain with Pain: Hazards of Antidepressant Use for Chronic Pain Relief

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The paradox of relieving chronic pain with an antidepressant (and a new set of symptoms).

Study Suggests Mania More Common in Psychosis When Antidepressants Used

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A prospective cohort study of those labeled high risk for psychosis finds a higher prevalence of antidepressant use among those who develop manic symptoms.