Clinical Trials Show Antidepressants “Not Beneficial in the Long Term”

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Clinical trials also consistently fail to measure and report long-term harmful effects.

Researchers: “Antidepressants Should Not be Used for Adults with Major Depressive Disorder”

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A new review, published in BMJ Evidence-Based Medicine, concludes that antidepressants should not be used as the risks outweigh evidence for benefits.
sertraline antidepressant withdrawal

Ambushed by Antidepressant Withdrawal: The Escape Story

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I’m alive. More than 30,000 veterans in the past decade alone are not. I was not warned of the risks of this drug. I was not told that once on it, I might never be able to get off it, or the nightmare that would ensue when I tried. I know millions of others were not told either.

Zoloft Does Not Improve Depression, Even in Severe Cases, Study Finds

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Despite their finding, the researchers suggest that SSRIs be given to people who do not meet criteria for depression or anxiety.

Antidepressant Use Associated With More Violent Suicide Attempts

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A new study found that taking an antidepressant medication was associated with a heightened risk of suicide using violent means.

Antidepressant Use Does Not Prevent Suicide, Study Finds

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A new study has found that antidepressants are ineffective for reducing suicide attempts. Researchers report that the risk of suicide is particularly high in the first month after starting an antidepressant.

Therapy Gets More Effective Over Time While Antidepressants Decrease in Effectiveness

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New review of long-term depression data finds psychotherapy more effective over time whereas antidepressants decrease in effectiveness.

Guidelines Recommending Antidepressants “in Contradiction with the Current Evidence”

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Researchers critique the German S3 guidelines for depression promoting antidepressants.

Risk of Depressive Relapse Three Times Higher After Previous Antidepressant Use

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A new study found that having been prescribed an antidepressant previously was associated with an increased risk of depressive relapse.

Adding Fluoxetine to Therapy Not Superior to Therapy Alone in Depressed Teens

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The addition of fluoxetine to CBT did not further reduce depressive symptoms in young people with moderate-to-severe depression.

Antidepressants Blunt Ability to Feel Empathy

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A new study suggests that taking antidepressants impairs empathy, while the experience of depression itself does not.
A bottle of pills. Some are spilled out.

Antidepressant Use More Than Doubles Risk of Suicide Attempts

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Throughout the past two decades, studies have warned of increased suicide rates in those taking antidepressants, especially in children and adolescents. Researchers also documented...

Anticholinergic Psychiatric Drugs Linked to a 50% Increase in Dementia

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People who take anticholinergic drugs, such as antidepressants and antipsychotics, are at a 50% higher risk of dementia.

Researcher Critiques Misleading Claims About Antidepressants

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Recent claims about antidepressant effectiveness have been based on misleading statements and misunderstandings of the science.

Children Taking ADHD Drugs More Likely to Take Antidepressants as Teens

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Adhering to a commonly prescribed medication for ADHD in children is associated with higher chances of being prescribed antidepressants in adolescence.

Exposure to Antidepressants in the Womb Linked to Autism

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Researchers, publishing in Toxicology Research, review the evidence that antidepressant exposure in the womb is linked to autism spectrum disorders (ASD) in humans.

Exposure to Antidepressants in the Womb Linked to Autistic Behavior in Mice

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Researchers experimenting on mice found that exposure to fluoxetine (Prozac) in utero resulted in behaviors considered in animal studies to be analogous to autism in humans.

Antidepressant Use Linked to Longer, More Frequent Psychiatric Rehospitalization

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New study finds that antidepressants may negatively impact recovery after psychiatric hospitalization.

The Effects of Antidepressant Exposure Across Generations: An Interview with Dr. Vance Trudeau

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Dr. Vance Trudeau discusses his study's finding that antidepressants may have far-reaching, adverse effects that last up to three generations.

Combining Mirtazapine with Existing SSRI or SNRI Does Not Improve Depressive Symptoms

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Study finds combining mirtazapine with an SSRI or SNRI is not clinically effective for improving depression in primary care patients who remained depressed after taking an SSRI or SNRI.

Does Active Placebo Response Explain Antidepressant Results?

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A new study investigated whether participants guessing if they have an antidepressant or placebo affects response rates.

New Study Finds Limited Effectiveness for Antidepressants After Stroke

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The researchers found that although antidepressants had a slight short-term effect on reducing the likelihood of depression diagnosis, there was no long-term improvement, nor any improvement in motor functioning.

Researchers Challenge Interpretation of Antidepressant Meta-analysis

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Researchers question the overstated results of a large antidepressant meta-analysis and point to cultural pressures to turn to these drugs for a quick fix.

Researchers Push Back Against Recommendation to Combine Antidepressants for Suicide Prevention

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Researchers challenge the recommendation of starting two antidepressants simultaneously to increase preventative effects against suicide.

Researchers Ask, ‘Why Do Antidepressants Stop Working?’

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An international group of researchers, including several with financial ties to manufacturers of antidepressants, explore possible explanations for why long-term users of antidepressants become chronically depressed.