JAMA Psychiatry Retracts Antidepressant Study

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Once an appropriate statistical method was used, the study findings were ā€œno longer valid,ā€ according to the editors of JAMA and JAMA Psychiatry.

New Analysis: Antidepressants Still Linked to Suicide

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ā€œThis is remarkable for drugs that are used to treat depressive symptoms,ā€ write the researchers.

No Good Evidence That Antidepressants Prevent Relapse

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Trials of antidepressants for relapse prevention are confounded by withdrawal effects caused by the drugs.

Antidepressant Misinformation Promoted on Popular Websites

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A new study indicates that popular online resources do not accurately present the scientific evidence on the risks and benefits of antidepressants.

Antidepressant Use Continues to Climb Among Youth on Medicaid

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New study finds that Medicaid enrolled youth were 14 times more likely to be on an antidepressant in 2014 than in 1987.

Researchers Find Paroxetine Harms Developing Brain

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Researchers at Johns Hopkins test paroxetine on developing brain cells and discover numerous neurotoxic effects.

Suicide Warning on Antidepressant Label is Justified, Researchers Say

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Researchers confirm that the suicide warning for antidepressants is justified by the evidence and that claims that the warning is harmful lack support.

Researchers: Antidepressant Withdrawal, Not ā€œDiscontinuation Syndromeā€

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Researchers suggest that the pharmaceutical industry had a vested interest in using the term ā€œdiscontinuationā€ in order to hide the severity of physical dependence and withdrawal reactions many people experience from antidepressants.
one yellow game piece among blue game pieces

Is There a Small Group for Whom Antidepressants Are Effective?

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In a new study, researchers found no evidence of antidepressant group variance, which means that there's no particular group of patients who improve more than others on the drug.
empty medical waiting room

Higher Drop-Out Rates for Those Taking Antidepressants

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A review of 73 antidepressant studies finds that 12% more people drop out of clinical trials when taking antidepressants than when taking placebo, evidence that many find the adverse effects of antidepressants difficult to tolerate.
colorful painting of brain

Researchers Fail to Predict Antidepressant Treatment Success

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In a new study published in JAMA Psychiatry, researchers investigated whether they could use EEG (electroencephalograph) technology to predict whether people would feel better...

Researchers Set the Record Straight on Controversial Zoloft Study

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An issue of Lancet Psychiatry is devoted to clarifying the lack of efficacy for Zoloft (sertraline).

How Antidepressants Shape Young Women’s Sense of Self

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Young women’s narratives indicate ways antidepressants have shaped their sense of self.

No Matter Which Measure You Use, Antidepressants Aren’t That Effective

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Researchers compared the efficacy of antidepressants using different rating scales and found them to be no different—just slightly better than placebo, and not meeting the criteria for clinical significance.

Psychotherapy Less Effective for People in Poverty and Those on Antidepressants

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A new study finds poorer depression and anxiety outcomes in psychotherapy for people in economically deprived neighborhoods and those on antidepressants.

Fear and Belief in “Chemical Imbalance” Prevent People from Coming Off Antidepressants

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Researchers interviewed people who were given medical advice to discontinue antidepressants.

Fluoxetine Not Helpful for Children with Autism

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A clinical trial finds Prozac no better than placebo for improving repetitive behaviors.

Researchers Challenge Evidence for Antidepressants in Youth

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Researchers shed light on the precarious nature of evidence from efficacy trials of antidepressant medication to treat symptoms of major depressive disorder in children and adolescents.

NICE Guideline Update Acknowledges Severe Antidepressant Withdrawal

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A new update to the NICE guideline for depression suggests providers discuss long-term, severe antidepressant withdrawal symptoms.

Clinical Trials Show Antidepressants ā€œNot Beneficial in the Long Termā€

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Clinical trials also consistently fail to measure and report long-term harmful effects.

Researchers: ā€œAntidepressants Should Not be Used for Adults with Major Depressive Disorderā€

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A new review, published in BMJ Evidence-Based Medicine, concludes that antidepressants should not be used as the risks outweigh evidence for benefits.
sertraline antidepressant withdrawal

Ambushed by Antidepressant Withdrawal: The Escape Story

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I’m alive. More than 30,000 veterans in the past decade alone are not. I was not warned of the risks of this drug. I was not told that once on it, I might never be able to get off it, or the nightmare that would ensue when I tried. I know millions of others were not told either.

Zoloft Does Not Improve Depression, Even in Severe Cases, Study Finds

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Despite their finding, the researchers suggest that SSRIs be given to people who do not meet criteria for depression or anxiety.

Antidepressant Use Associated With More Violent Suicide Attempts

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A new study found that taking an antidepressant medication was associated with a heightened risk of suicide using violent means.

Antidepressant Use Does Not Prevent Suicide, Study Finds

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A new study has found that antidepressants are ineffective for reducing suicide attempts. Researchers report that the risk of suicide is particularly high in the first month after starting an antidepressant.