Monday, November 28, 2022

Very Slow Taper Best for Antipsychotic Discontinuation

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An article in JAMA Psychiatry advises very slow tapering for best results when discontinuing antipsychotic drugs.

Study Finds Improved Functioning for ‘Schizophrenia’ Without Antipsychotics

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Long-term treatment with antipsychotic drugs is currently considered the standard treatment for patients diagnosed with ‘schizophrenia.’ A new study challenges this practice, however. The...

Scientists Clarify Risks of Augmenting with Antipsychotic Medications for Depression

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The researchers found that while antipsychotic drugs may be slightly more effective than alternative antidepressants, they come with a much higher side effect burden.

Study Suggests Long-Term Antipsychotic Use May Result in Poorer Cognitive Functioning

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Association found between long-term antipsychotic use and poorer performance on cognitive tasks in adults diagnosed with ‘schizophrenia.’

Patients With Schizophrenia Show Better Work Functioning Off Antipsychotics

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20-year follow-up study finds that after four years, patients not prescribed antipsychotics have significantly better work functioning.

Review Explores First-Person Experiences of People Taking Antipsychotics

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A new systematic review finds that patients report reduced symptoms but also loss of self and agency while taking antipsychotics.

A Guide to Minimal Use of Neuroleptics

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This guide, by psychiatrists Volkmar Aderhold and Peter Stastny, provides a comprehensive review of antipsychotics and an evidence-based rationale for avoiding their use in first-episode psychosis, and for minimizing their long-term use.
Yellow sign reading "Cognitive Hazard"

Discontinuation of Antipsychotics Improves Cognitive Functioning

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A study, recently published in Psychological Medicine, examined the cognitive functioning of individuals with schizophrenia who discontinued antipsychotics, and those who maintained their antipsychotic...

Study Shows Clozapine Can Result in Serious Gastrointestinal Complications

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A large observational study published in CNS Drugs sheds light on serious adverse effects of the ‘gold standard’ antipsychotic Clozapine.

Review Questions Long Term Use of Antipsychotics

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Patients who recover from a single episode of psychosis are often prescribed antipsychotics long-term, despite a lack of evidence for this practice

Abilify Can Worsen Psychosis & Aggression

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In a systematic literature review, researchers from Canada and Japan found that the antipsychotic aripiprazole (Abilify) was significantly and causally related to increased increased...

Antipsychotics Worsen Cognitive Functioning in First-Episode Psychosis

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Withholding antipsychotics may be beneficial for memory, the researchers write.

Greater Exposure to Antipsychotics Associated with Worse Long-Term Outcomes

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A new study finds adverse long-term consequences associated with the increased use of antipsychotics in first-episode psychosis.

How Do We Test the Effects of Long-Term Exposure to Antipsychotics?

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A new attempt to study the neurological effects of long-term exposure to antipsychotics uses healthy volunteers on minimal doses for 15 days.

Better Outcomes Off Medication for Those Recovered from First-Episode Schizophrenia

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A new study has found that of 10 people who were fully recovered from their first episode of schizophrenia (FES), those not taking antipsychotics did better in terms of cognitive, social, and role functioning—and reached full recovery more quickly.

Does Longer Duration of Untreated Psychosis Cause Worse Outcomes?

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New research counters the long-held assumption that a longer duration of untreated psychosis is associated with worse outcomes.

Two-Thirds of Schizophrenia Patients Do Not Remit on Antipsychotics

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A new analysis of antipsychotic treatment of schizophrenia (published in Schizophrenia Bulletin) has found that two-thirds of patients treated this way do not experience symptom remission.

Reduction/Discontinuation of Antipsychotics Produces Higher Long-Term Recovery

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A study published today in the American Medical Association's journal JAMA Psychiatry reports that patients whose antipsychotic treatment was reduced or discontinued (DR) experienced a recovery...

Patients Complain about Antipsychotic Medications Inducing “Zombie-like” State

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People who take antipsychotic medications experience many side effects which have "major disruptive impact on their lives," according to research in the Journal of Mental Health Nursing.

Study Explores Cognitive Effects of Antipsychotics

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Reduced usage of antipsychotics in first-episode psychosis was associated with improved executive functioning.

Antipsychotics Often Prescribed Without Informed Consent

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New research reveals that patients are often not given fully informed consent before being prescribed antipsychotics.

FDA Warns About New Impulse-Control Problems Associated With Abilify

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Yesterday, the US Food and Drug Administration (FDA) released a warning that the antipsychotic drug aripiprazole or Abilify is associated with compulsive and uncontrollable...

Anticholinergic Drugs Increase Risk of Cognitive Decline

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A new study finds that anticholinergic drugs, like antidepressants and antipsychotics, are associated with mild cognitive decline.

In Chronic Patients, Antipsychotics Have Limited Efficacy in Reducing Symptoms

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A large review and meta-analysis of 167 studies across 60 years dissects placebo-controlled randomized controlled trials of antipsychotic drugs.

Acute Respiratory Failure More Likely in COPD Patients Prescribed Antipsychotics

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Researchers recommend that healthcare professionals be vigilant regarding the signs of respiratory failure among patients with COPD who are receiving antipsychotics, especially during the initial treatment phase.

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