Kindred Spirit: If you were pushed to take Saphris in 2008, it would have been before it was approved for use. What happens is that after a company finishes its actual RCTs for NDA purposes, it then begins doing extension trials, which are unblinded and meant to show that the drug can be taken “safely” for longer periods of times. In this instance, there were so few people who were actually enrolled in placebo controlled trials that there was very little “safety data” with robust numbers of patients exposed to the drugs. So they ran these unblinded studies to get the exposure numbers up, which helps make it seem the drug has been throughly tested. And it meant a drug company payment to the psychiatrist who was trying to get you to take Saphris.