Study Reduces Over-prescription of Antipsychotics in Older Adults

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New intervention shows promise in reducing over-prescription of off-label antipsychotics in older adults.

New Research Suggests Brain Abnormalities in ā€˜Schizophreniaā€™ May Result From Antipsychotics

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Study finds that reduced cortical thickness and brain surface area associated with 'schizophrenia' may result from antipsychotic drug use.

FDA Defends Decision to Approve Digital Aripiprazole

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Members of the U.S. Food and Drug Administrationā€™s Psychiatry Products division go on the defensive in a new article, responding to concerns about the agencyā€™s approval of digital aripiprazole.

Effort to Tackle Overuse of Antipsychotics in Older Adults Backfires

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A partnership designed to decrease antipsychotic use in elderly patients may have led to increased use of medications with even worse risk/benefit profiles.

A Tale of Two Studies

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With increasing evidence that psychiatric drugs do more harm than good over the long term, the field of psychiatry often seems focused on sifting through the mounds of research data it has collected, eager to at last sit up and cry, hereā€™s a shiny speck of gold! Our drugs do work! One recently published study on withdrawal of antipsychotics tells of long-term benefits. A second tells of long-term harm. Which one is convincing?

Researchers Challenge Industry-Friendly Depression Guideline

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Review of a new mixed depression guideline reveals financial bias of guideline developers and lack of evidence supporting recommendations for prescribing of antipsychotics.

Vitamin B6 Effective in Reducing Antipsychotic Induced Akathisia

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A recent RCT showed that vitamin B6 is as effective as propranolol for the treatment of akathisia.

Reducing Antipsychotic Use May Improve Health for People with Mental Health Diagnoses

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A new study offers radical solutions for improving the cardiovascular health of people with mental health diagnoses: reducing antipsychotic prescriptions..

Anticholinergic Medications Linked to Dementia Similar to Early Alzheimerā€™s

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A new study, published in the Journal of Clinical Psychiatry, investigates the effects of anticholinergic medications, such as antidepressants and antipsychotics, on cognition in older adults diagnosed with schizophrenia.

Scientists Clarify Risks of Augmenting with Antipsychotic Medications for Depression

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The researchers found that while antipsychotic drugs may be slightly more effective than alternative antidepressants, they come with a much higher side effect burden.

Children Diagnosed with ADHD Younger are More Likely to get Multiple Medications

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New research demonstrates that children diagnosed with ADHD at younger ages are more likely than those diagnosed later to receive multiple medications within five years of their diagnosis.

Patients on Antipsychotics at High Risk for Cardiovascular Issues, Study Finds

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Antipsychotics present a known risk for major side effects. A new study suggests that certain antipsychotics may present a greater risk for cardiovascular disease than others.

Outcome Reporting Bias in Antipsychotic Medication Trials

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A new study in the journal Translational Psychiatry, an influential journal in biological psychiatry published by Nature, challenges the state of the research on antipsychotic drugs.

Inappropriate Use of Antipsychotics on Adults with Intellectual and Developmental Disabilities

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One-third of adults with an intellectual or developmental disability are dispensed antipsychotics, despite having no existing psychiatric diagnosis.

Increased Risk of Movement Disorders From Antipsychotics in Persons with Intellectual Disabilities

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Large cohort study demonstrates that those with an intellectual disability are at an increased risk for movement disorder side effects of antipsychotics.

Patients With Schizophrenia Show Better Work Functioning Off Antipsychotics

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20-year follow-up study finds that after four years, patients not prescribed antipsychotics have significantly better work functioning.

In Chronic Patients, Antipsychotics Have Limited Efficacy in Reducing Symptoms

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A large review and meta-analysis of 167 studies across 60 years dissects placebo-controlled randomized controlled trials of antipsychotic drugs.

Half of First-Episode Patients Respond to Antipsychotics

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No placebo controlled trials provide evidence of antipsychotics in first-episode psychosis.

Large Study Confirms Elevated Risk of Diabetes When Prescribed Antipsychotics

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A large longitudinal study finds once more that being prescribed antipsychotics significantly increases the risk of diabetes.

Study Shows Clozapine Can Result in Serious Gastrointestinal Complications

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A large observational study published in CNS Drugs sheds light on serious adverse effects of the ā€˜gold standardā€™ antipsychotic Clozapine.

ā€˜Salami Slicingā€™ Found in Analyses of Antipsychotic Trials

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Evidence of duplicate publishing in articles analyzing data from clinical trials testing second-generation antipsychotics for depression

PTSD and Psychiatric Medication Linked to Dementia in Older Veterans

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Veterans diagnosed with PTSD and taking SSRIs, novel antidepressants, or atypical antipsychotics are more likely to develop dementia.

Psychiatry Defends Its Antipsychotics: A Case Study of Institutional Corruption

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Jeffrey LIeberman and colleagues have published a paper in the American Journal of Psychiatry stating that there is no evidence that psychiatric drugs cause long-term harm, and that the evidence shows that these drugs provide a great benefit to patients. A close examination of their review reveals that it is a classic example of institutional corruption, which was meant to protect guild interests.

Study Explores Cognitive Effects of Antipsychotics

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Reduced usage of antipsychotics in first-episode psychosis was associated with improved executive functioning.

Danish Study Finds Better 10-year Outcomes in Patients Off Antipsychotics

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Study finds that 74% of patients with a psychotic disorder off antipsychotics at end of 10 years are in remission.