Thank you for your in-depth scientific analysis; I always appreciate truth. The power of placebos and especially nocebos is greatly underestimated/misunderstood. Moreover, all studies shorter than 5-10 years are predicated on the assumption that depression is a disease. Otherwise, it would be assumed that any study shorter than 5 years would be unable to assess whether outcomes were due to the effects of the drugs or a reduction of depression. Light doses of morphine can outperform “antidepressants” during most trial periods but will worsen depression significantly over time.