PROTOCOLIZE RESEARCH REVIEW Thank you for your review of this study. You and other writers of Mad In America have gained crucial experience in examining research, consisting in tests and analysis criteria. Isn’t it time to compile all these criteria in a protocol, allowing to carry out a systematic review of research according to predictable and rigorously defined criteria? We always find the same criteria in your articles and those of other editors: _ representative vs non-representative population _ placebo study vs withdrawal study _ naive population vs non-naive population _ Confounding factors (including medication) _ short term vs long term _ protection of the safety (in particular due to withdrawal) Etc. There is not much missing to compile all these criteria in a systematic analysis protocol. I would like different Mad In America editors to come together to establish such a protocol, which would guide the editors in their analysis of studies. It makes it possible to assess the quality of studies in a stricter, more in-depth and better defined manner. Such a protocol could eventually become a recognized standard for evaluating scientific research.